Förster Resonance Energy Transfer Nanoplatform Based on Recognition-Induced Fusion/Fission of DNA Mixed Micelles for Nucleic Acid Sensing
نویسندگان
چکیده
The dynamic nature of micellar nanostructures is employed to form a self-assembled Förster resonance energy transfer (FRET) nanoplatform for enhanced sensing DNA. platform consists lipid oligonucleotide FRET probes incorporated into scaffolds, where single recognition events result in fusion and fission DNA mixed micelles, triggering the fluorescence response multiple rather than pair. In comparison conventional substrates donor interacts with acceptor, multiplex system showed ∼20- ∼3-fold enhancements limit detection efficiency, respectively. This supramolecular signal amplification approach could potentially be used improve FRET-based diagnostic assays nucleic acid non-DNA based targets.
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2021
ISSN: ['1936-0851', '1936-086X']
DOI: https://doi.org/10.1021/acsnano.1c00156